Assay Detail
Binding
CHEMBL801602
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In vitro inhibition against human plasma renin.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Plasma |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
alpha-Methylproline-containing renin inhibitory peptides: in vivo evaluation in an anesthetized, ganglion-blocked, hog renin infused rat model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.92 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3143428 | — | — | 1 | 8.70 |
| CHEMBL3143432 | — | — | 1 | 8.46 |
| CHEMBL3142175 | — | — | 1 | 7.62 |
| CHEMBL3143429 | — | — | 1 | 7.44 |
| CHEMBL3143431 | — | — | 1 | 7.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3143428 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3143432 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL3142175 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3143429 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3143431 | — | IC50 | = | 43.0 | nM | 7.37 |