Assay Detail
Binding
CHEMBL801614
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Effective concentration that reduces HIV-induced cytopathic effect by 50% was determined by reverse transcriptase (RT) assay.
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and anti-HIV evaluation of D4T and D4T 5'-monophosphate prodrugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.39 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.00 |
| CHEMBL440551 | — | — | 1 | 7.70 |
| CHEMBL166784 | — | — | 1 | 7.70 |
| CHEMBL170331 | — | — | 1 | 7.40 |
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 7.30 |
| CHEMBL352398 | — | — | 1 | 7.30 |
| CHEMBL353179 | — | — | 1 | 7.30 |
| CHEMBL166614 | — | — | 1 | 7.10 |
| CHEMBL170006 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL440551 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL166784 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL170331 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL991 | STAVUDINE | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL352398 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL353179 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL166614 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL170006 | — | EC50 | = | 200.0 | nM | 6.70 |