Assay Detail
Binding
CHEMBL801662
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Inhibition of human renin at pH 6.0
9
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Inhibition of porcine pepsin by two substrate analogues containing statine. The effect of histidine at the P2 subsite on the inhibition of aspartic proteinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.40 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL154795 | — | — | 1 | 8.85 |
| CHEMBL90896 | — | — | 2 | 8.82 |
| CHEMBL362209 | — | — | 1 | 8.59 |
| CHEMBL3349390 | — | — | 1 | 8.46 |
| CHEMBL3349392 | — | — | 1 | 8.26 |
| CHEMBL347171 | — | — | 1 | 8.15 |
| CHEMBL2311113 | — | — | 1 | 8.00 |
| CHEMBL3142766 | — | — | 1 | 7.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL154795 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL90896 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL90896 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL362209 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL3349390 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL3349392 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL347171 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2311113 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3142766 | — | IC50 | = | 17.0 | nM | 7.77 |