Assay Detail
Functional
CHEMBL801669
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against human plasma renin at pH 7.4
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Plasma |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Water-soluble renin inhibitors: design of a subnanomolar inhibitor with a prolonged duration of action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 8.13 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58263 | — | — | 1 | 9.24 |
| CHEMBL299055 | — | — | 1 | 8.96 |
| CHEMBL345043 | — | — | 1 | 8.89 |
| CHEMBL303076 | — | — | 1 | 8.82 |
| CHEMBL61420 | — | — | 1 | 8.60 |
| CHEMBL59135 | — | — | 1 | 8.14 |
| CHEMBL61428 | — | — | 1 | 8.06 |
| CHEMBL61777 | — | — | 1 | 8.02 |
| CHEMBL58968 | — | — | 1 | 8.00 |
| CHEMBL59887 | — | — | 1 | 7.96 |
| CHEMBL300337 | ENALKIREN | 2.0 | 1 | 7.85 |
| CHEMBL58859 | — | — | 1 | 7.85 |
| CHEMBL305162 | — | — | 1 | 7.58 |
| CHEMBL59236 | — | — | 1 | 7.57 |
| CHEMBL58351 | — | — | 1 | 7.34 |
| CHEMBL294379 | — | — | 1 | 7.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58263 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL299055 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL345043 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL303076 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL61420 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL59135 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL61428 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL61777 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL58968 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL59887 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL300337 | ENALKIREN | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL58859 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL305162 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL59236 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL58351 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL294379 | — | IC50 | = | 59.0 | nM | 7.23 |