Assay Detail
Binding
CHEMBL801744
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In vitro inhibition of monkey renin.
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cercopithecidae |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 9.03 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL88091 | — | — | 1 | 9.80 |
| CHEMBL313063 | — | — | 1 | 9.70 |
| CHEMBL315380 | — | — | 1 | 9.64 |
| CHEMBL88069 | — | — | 1 | 9.57 |
| CHEMBL315211 | — | — | 1 | 9.55 |
| CHEMBL316208 | — | — | 1 | 9.46 |
| CHEMBL34894 | — | — | 1 | 9.44 |
| CHEMBL263531 | — | — | 1 | 9.32 |
| CHEMBL405227 | — | — | 1 | 9.30 |
| CHEMBL431217 | — | — | 1 | 9.27 |
| CHEMBL314066 | — | — | 1 | 9.24 |
| CHEMBL430634 | — | — | 1 | 9.23 |
| CHEMBL300337 | ENALKIREN | 2.0 | 1 | 9.12 |
| CHEMBL293196 | — | — | 1 | 9.08 |
| CHEMBL85672 | — | — | 1 | 9.04 |
| CHEMBL420417 | — | — | 1 | 8.63 |
| CHEMBL60610 | — | — | 1 | 8.57 |
| CHEMBL315992 | — | — | 1 | 8.47 |
| CHEMBL316218 | — | — | 1 | 8.44 |
| CHEMBL87389 | — | — | 1 | 8.39 |
| CHEMBL316176 | — | — | 1 | 7.86 |
| CHEMBL86374 | — | — | 1 | 7.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL88091 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL313063 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL315380 | — | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL88069 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL315211 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL316208 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL34894 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL263531 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL405227 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL431217 | — | IC50 | = | 0.54 | nM | 9.27 |
| CHEMBL314066 | — | IC50 | = | 0.581 | nM | 9.24 |
| CHEMBL430634 | — | IC50 | = | 0.59 | nM | 9.23 |
| CHEMBL300337 | ENALKIREN | IC50 | = | 0.76 | nM | 9.12 |
| CHEMBL293196 | — | IC50 | = | 0.83 | nM | 9.08 |
| CHEMBL85672 | — | IC50 | = | 0.91 | nM | 9.04 |
| CHEMBL420417 | — | IC50 | = | 2.34 | nM | 8.63 |
| CHEMBL60610 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL315992 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL316218 | — | IC50 | = | 3.61 | nM | 8.44 |
| CHEMBL87389 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL316176 | — | IC50 | = | 13.7 | nM | 7.86 |
| CHEMBL86374 | — | IC50 | = | 33.0 | nM | 7.48 |