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Assay Detail

CHEMBL801753

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against monkey renin
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cercopithecidae
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Renin (CHEMBL286)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation.
Rao CM, Scarborough PE, Kay J, Batley B, Rapundalo S, Klutchko S, Taylor MD, Lunney EA, Humblet CC, Dunn BM.
J Med Chem (1993) 36 : 2614 -2620
PubMed 8410973 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 9.13 9.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL316095 1 9.70
CHEMBL62380 1 9.70
CHEMBL87025 1 9.70
CHEMBL88654 1 9.52
CHEMBL84970 1 9.52
CHEMBL313773 1 9.52
CHEMBL287423 1 9.40
CHEMBL329220 1 9.22
CHEMBL88340 1 9.15
CHEMBL88415 1 9.10
CHEMBL88356 1 9.05
CHEMBL3348525 1 8.96
CHEMBL88526 1 7.89
CHEMBL90683 1 7.36
CHEMBL418948 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL316095 IC50 = 0.2 nM 9.70
CHEMBL62380 IC50 = 0.2 nM 9.70
CHEMBL87025 IC50 = 0.2 nM 9.70
CHEMBL88654 IC50 = 0.3 nM 9.52
CHEMBL84970 IC50 = 0.3 nM 9.52
CHEMBL313773 IC50 = 0.3 nM 9.52
CHEMBL287423 IC50 = 0.4 nM 9.40
CHEMBL329220 IC50 = 0.6 nM 9.22
CHEMBL88340 IC50 = 0.7 nM 9.15
CHEMBL88415 IC50 = 0.8 nM 9.10
CHEMBL88356 IC50 = 0.9 nM 9.05
CHEMBL3348525 IC50 = 1.1 nM 8.96
CHEMBL88526 IC50 = 13.0 nM 7.89
CHEMBL90683 IC50 = 44.0 nM 7.36
CHEMBL418948 IC50 > 1.0 nM -