Assay Detail

CHEMBL801754

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Binding

Inhibitory activity against renin in monkey plasma at pH 7.7

ChEMBL ↗

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Target

Renin (CHEMBL286) ↗

Open DB target context

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Primary target Renin

CHEMBL286

Anchored from Assay target.

Protein identity Renin

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Cercopithecidae
Tissue	Plasma
Confidence	8 — Homologous single protein target
Curated By	Autocuration

Target

Renin (CHEMBL286) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

C-terminal modifications of nonpeptide renin inhibitors: improved oral bioavailability via modification of physicochemical properties.

Boyd SA, Fung AK, Baker WR, Mantei RA, Armiger YL, Stein HH, Cohen J, Egan DA, Barlow JL, Klinghofer V.
J Med Chem (1992) 35 : 1735 -1746
PubMed 1588555 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.64	8.64

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL300337	ENALKIREN	2.0	1	8.64

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL300337	ENALKIREN	IC50	=	2.3	nM	8.64