Assay Detail
Binding
CHEMBL801756
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The compound was evaluated for inhibitory activity against monkey plasma renin.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cercopithecidae |
| Tissue | Plasma |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Peptidomimetic inhibitors of renin incorporating topographically modified isosteres spanning the P1( P3)-P1' sites
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.73 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62380 | — | — | 1 | 9.70 |
| CHEMBL308894 | — | — | 1 | 7.96 |
| CHEMBL306917 | — | — | 1 | 7.73 |
| CHEMBL304849 | — | — | 1 | 7.22 |
| CHEMBL64984 | — | — | 1 | 7.09 |
| CHEMBL306228 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62380 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL308894 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL306917 | — | IC50 | = | 18.5 | nM | 7.73 |
| CHEMBL304849 | — | IC50 | = | 60.5 | nM | 7.22 |
| CHEMBL64984 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL306228 | — | IC50 | = | 202.0 | nM | 6.70 |