Assay Detail
Binding
CHEMBL801758
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The concentration producing 50% inhibition of renin activity in monkey plasma was determined by radioimmunoassay.
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cercopithecidae |
| Tissue | Plasma |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of potent, selective, and orally active fluorine-containing renin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 9.02 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL286147 | — | — | 1 | 10.00 |
| CHEMBL31910 | — | — | 1 | 9.68 |
| CHEMBL286951 | — | — | 1 | 9.66 |
| CHEMBL29323 | — | — | 1 | 9.64 |
| CHEMBL281531 | — | — | 1 | 9.64 |
| CHEMBL21684 | — | — | 1 | 9.62 |
| CHEMBL28702 | — | — | 1 | 9.60 |
| CHEMBL32575 | — | — | 1 | 9.55 |
| CHEMBL29103 | — | — | 1 | 9.52 |
| CHEMBL31259 | — | — | 1 | 9.51 |
| CHEMBL282756 | — | — | 1 | 9.49 |
| CHEMBL285095 | — | — | 1 | 9.46 |
| CHEMBL31956 | — | — | 1 | 9.46 |
| CHEMBL286085 | — | — | 1 | 9.44 |
| CHEMBL31679 | — | — | 1 | 9.40 |
| CHEMBL405764 | — | — | 1 | 9.38 |
| CHEMBL284254 | — | — | 1 | 9.36 |
| CHEMBL28408 | — | — | 1 | 9.34 |
| CHEMBL405227 | — | — | 1 | 9.30 |
| CHEMBL31420 | — | — | 1 | 9.24 |
| CHEMBL285207 | — | — | 1 | 9.21 |
| CHEMBL31889 | — | — | 1 | 9.16 |
| CHEMBL31550 | — | — | 1 | 9.15 |
| CHEMBL31621 | — | — | 1 | 9.10 |
| CHEMBL30920 | — | — | 1 | 9.09 |
| CHEMBL1790136 | — | — | 1 | 9.09 |
| CHEMBL265316 | — | — | 1 | 9.06 |
| CHEMBL262107 | — | — | 1 | 9.05 |
| CHEMBL31268 | — | — | 1 | 9.04 |
| CHEMBL280818 | — | — | 1 | 8.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL286147 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL31910 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL286951 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL29323 | — | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL281531 | — | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL21684 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL28702 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL32575 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL29103 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL31259 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL282756 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL31956 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL285095 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL286085 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL31679 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL405764 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL284254 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL28408 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL405227 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL31420 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL285207 | — | IC50 | = | 0.62 | nM | 9.21 |
| CHEMBL31889 | — | IC50 | = | 0.69 | nM | 9.16 |
| CHEMBL31550 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL31621 | — | IC50 | = | 0.79 | nM | 9.10 |
| CHEMBL30920 | — | IC50 | = | 0.81 | nM | 9.09 |
| CHEMBL1790136 | — | IC50 | = | 0.82 | nM | 9.09 |
| CHEMBL265316 | — | IC50 | = | 0.87 | nM | 9.06 |
| CHEMBL262107 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL31268 | — | IC50 | = | 0.92 | nM | 9.04 |
| CHEMBL280818 | — | IC50 | = | 1.17 | nM | 8.93 |
| CHEMBL287423 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL32239 | — | IC50 | = | 1.49 | nM | 8.83 |
| CHEMBL280543 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL284922 | — | IC50 | = | 1.89 | nM | 8.72 |
| CHEMBL28132 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL287265 | — | IC50 | = | 2.33 | nM | 8.63 |
| CHEMBL29041 | — | IC50 | = | 2.46 | nM | 8.61 |
| CHEMBL28311 | — | IC50 | = | 2.96 | nM | 8.53 |
| CHEMBL262385 | — | IC50 | = | 3.55 | nM | 8.45 |
| CHEMBL31438 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL31201 | — | IC50 | = | 12.3 | nM | 7.91 |
| CHEMBL285778 | — | IC50 | = | 19.1 | nM | 7.72 |
| CHEMBL32046 | — | IC50 | = | 97.8 | nM | 7.01 |
| CHEMBL285884 | — | IC50 | = | 164.0 | nM | 6.79 |