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Assay Detail

CHEMBL801874

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Tested for growth inhibition against SKOV3 tumor cell line(human ovarian).
20
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SK-OV-3
Confidence 1 — Organism
Curated By Expert

Target

SK-OV-3 (CHEMBL614925)
Type CELL-LINE
Organism Homo sapiens

Publication

5-Amino-1-(chloromethyl)-1,2-dihydro-3H-benz[e]indoles: relationships between structure and cytotoxicity for analogues bearing different DNA minor groove binding subunits.
Atwell GJ, Milbank JJ, Wilson WR, Hogg A, Denny WA.
J Med Chem (1999) 42 : 3400 -3411
PubMed 10464026 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 8.56 9.62

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL117142 1 9.62
CHEMBL113847 1 9.32
CHEMBL37705 3 9.27
CHEMBL333848 1 9.17
CHEMBL325178 1 8.92
CHEMBL325693 1 8.82
CHEMBL314487 1 8.73
CHEMBL116575 1 8.73
CHEMBL419586 1 8.72
CHEMBL115450 1 8.57
CHEMBL325876 1 8.52
CHEMBL324721 1 8.46
CHEMBL114587 1 8.38
CHEMBL419219 1 8.28
CHEMBL113953 1 7.89
CHEMBL114467 1 7.76
CHEMBL114001 1 7.66
CHEMBL326732 1 7.31

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL117142 IC50 = 0.24 nM 9.62
CHEMBL113847 IC50 = 0.48 nM 9.32
CHEMBL37705 IC50 = 0.54 nM 9.27
CHEMBL333848 IC50 = 0.68 nM 9.17
CHEMBL37705 IC50 = 1.04 nM 8.98
CHEMBL325178 IC50 = 1.2 nM 8.92
CHEMBL325693 IC50 = 1.5 nM 8.82
CHEMBL116575 IC50 = 1.86 nM 8.73
CHEMBL314487 IC50 = 1.86 nM 8.73
CHEMBL419586 IC50 = 1.9 nM 8.72
CHEMBL115450 IC50 = 2.7 nM 8.57
CHEMBL325876 IC50 = 3.0 nM 8.52
CHEMBL324721 IC50 = 3.5 nM 8.46
CHEMBL114587 IC50 = 4.2 nM 8.38
CHEMBL419219 IC50 = 5.3 nM 8.28
CHEMBL37705 IC50 = 7.9 nM 8.10
CHEMBL113953 IC50 = 13.0 nM 7.89
CHEMBL114467 IC50 = 17.3 nM 7.76
CHEMBL114001 IC50 = 22.0 nM 7.66
CHEMBL326732 IC50 = 49.0 nM 7.31