Assay Detail
Binding
CHEMBL801927
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Inhibition of recombinant rat Sorbitol dehydrogenase
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
SAR and species/stereo-selective metabolism of the sorbitol dehydrogenase inhibitor, CP-470,711.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.29 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL36368 | — | — | 1 | 8.10 |
| CHEMBL34965 | — | — | 1 | 7.57 |
| CHEMBL284537 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL36368 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL34965 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL284537 | — | IC50 | = | 640.0 | nM | 6.19 |