Assay Detail
Binding
CHEMBL801928
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Inhibition of recombinant rat sorbitol dehydrogenase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
SAR and species/stereo-selective metabolism of the sorbitol dehydrogenase inhibitor, CP-470,711.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.60 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34667 | — | — | 1 | 8.30 |
| CHEMBL36514 | — | — | 1 | 7.77 |
| CHEMBL286539 | — | — | 1 | 7.75 |
| CHEMBL287890 | — | — | 1 | 7.54 |
| CHEMBL277816 | — | — | 1 | 6.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34667 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL36514 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL286539 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL287890 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL277816 | — | IC50 | = | 227.0 | nM | 6.64 |