Assay Detail
Binding
CHEMBL801946
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Tested for kinetic constant for the inhibition of recombinant human placental S-Adenosyl-L-homocysteine Hydrolase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Nucleic acid related compounds. 84. Synthesis of 6'-(E and Z)-halohomovinyl derivatives of adenosine, inactivation of S-adenosyl-L-homocysteine hydrolase, and correlation of anticancer and antiviral potencies with enzyme inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.58 | 7.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL608056 | — | — | 1 | 7.02 |
| CHEMBL2092790 | — | — | 1 | 6.96 |
| CHEMBL2092789 | — | — | 1 | 6.87 |
| CHEMBL604208 | — | — | 1 | 6.17 |
| CHEMBL610125 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL608056 | — | Ki | = | 96.0 | nM | 7.02 |
| CHEMBL2092790 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL2092789 | — | Ki | = | 134.0 | nM | 6.87 |
| CHEMBL604208 | — | Ki | = | 681.0 | nM | 6.17 |
| CHEMBL610125 | — | Ki | = | 1300.0 | nM | 5.89 |