Assay Detail
Binding
CHEMBL801948
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concentration dependent inhibition of S-Adenosyl-homocysteine hydrolase was determined by Kitz and Wilson method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.94 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308037 | — | — | 1 | 7.41 |
| CHEMBL77518 | — | — | 1 | 7.37 |
| CHEMBL606276 | — | — | 1 | 7.02 |
| CHEMBL605902 | — | — | 1 | 7.00 |
| CHEMBL605900 | — | — | 1 | 6.96 |
| CHEMBL3349025 | — | — | 1 | 6.65 |
| CHEMBL1288616 | — | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308037 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL77518 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL606276 | — | Ki | = | 94.6 | nM | 7.02 |
| CHEMBL605902 | — | Ki | = | 101.0 | nM | 7.00 |
| CHEMBL605900 | — | Ki | = | 111.0 | nM | 6.96 |
| CHEMBL3349025 | — | Ki | = | 224.0 | nM | 6.65 |
| CHEMBL1288616 | — | Ki | = | 670.0 | nM | 6.17 |