Assay Detail
Functional
CHEMBL802026
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to inhibit 50% growth of human ovarian cancer cell line(SK-OV-3) was measured
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-OV-3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, topoisomerase I inhibitory activity, and in vivo evaluation of 11-azacamptothecin analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.62 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13746 | — | — | 1 | 9.10 |
| CHEMBL13935 | — | — | 1 | 9.00 |
| CHEMBL276460 | — | — | 1 | 7.77 |
| CHEMBL13848 | — | — | 1 | 7.50 |
| CHEMBL275134 | — | — | 1 | 7.18 |
| CHEMBL13349 | — | — | 1 | 7.15 |
| CHEMBL13523 | — | — | 1 | 6.61 |
| CHEMBL268978 | — | — | 1 | 6.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13746 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL13935 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL276460 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL13848 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL275134 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL13349 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL13523 | — | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL268978 | — | IC50 | = | 243.0 | nM | 6.61 |