Assay Detail
Functional
CHEMBL802139
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In vitro cytotoxicity against SKOV-3 cells in the presence of 1 mM NADH co-factor and 1 ug/mL Escherichia coli B nitroreductase (NTR)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-OV-3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Nitrobenzyl carbamate prodrugs of enediynes for nitroreductase gene-directed enzyme prodrug therapy (GDEPT).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.00 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116759 | — | — | 1 | 7.41 |
| CHEMBL432797 | — | — | 1 | 6.58 |
| CHEMBL325046 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116759 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL432797 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL325046 | — | IC50 | > | 20000.0 | nM | - |