Assay Detail
Functional
CHEMBL802142
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro for cytotoxicity against SKOV-3 cells in the presence of 1 mM NADH co-factor and 1 ug/mL Escherichia coli B nitroreductase (NTR)
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-OV-3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Nitrobenzyl carbamate prodrugs of enediynes for nitroreductase gene-directed enzyme prodrug therapy (GDEPT).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.00 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23330 | TRETAZICAR | 2.0 | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23330 | TRETAZICAR | IC50 | = | 1010.0 | nM | 6.00 |