Assay Detail
Binding
CHEMBL802186
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In vitro for inhibitory activity against HIV-1 Reverse Transcriptase
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Non-nucleoside inhibitors of HIV-1 reverse transcriptase: molecular modeling and X-ray structure investigations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.46 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL85446 | — | — | 1 | 7.52 |
| CHEMBL87303 | — | — | 1 | 6.82 |
| CHEMBL46961 | — | — | 1 | 6.80 |
| CHEMBL430623 | — | — | 1 | 6.55 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.37 |
| CHEMBL351375 | — | — | 1 | 6.08 |
| CHEMBL163536 | — | — | 1 | 5.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL85446 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL87303 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL46961 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL430623 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL351375 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL163536 | — | IC50 | = | 8700.0 | nM | 5.06 |