Assay Detail
Functional
CHEMBL802209
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro cytotoxicity against SKOV3 cell proliferation after 18 hr exposure in presence of 1 mM NADH + NTR
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-OV-3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
A 2-nitroimidazole carbamate prodrug of 5-amimo-1-(chloromethyl)-3-[(5,6,7-trimethoxyindol-2-yl)carbony l]-1,2-dihydro-3H--benz[E]indole (amino-seco-CBI-TMI) for use with ADEPT and GDEPT.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.52 | 8.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL37705 | — | — | 1 | 8.94 |
| CHEMBL305925 | — | — | 1 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL37705 | — | IC50 | = | 1.14 | nM | 8.94 |
| CHEMBL305925 | — | IC50 | = | 8.0 | nM | 8.10 |