Assay Detail
Binding
CHEMBL802221
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Binding affinity against HIV reverse transcriptase (Estimated Ki)
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Stereochemistry of halopyridyl and thiazolyl thiourea compounds is a major determinant of their potency as nonnucleoside inhibitors of HIV-1 reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 5.85 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39999 | TROVIRDINE | 2.0 | 1 | 6.22 |
| CHEMBL295585 | — | — | 1 | 6.22 |
| CHEMBL294743 | — | — | 1 | 5.96 |
| CHEMBL302866 | — | — | 1 | 5.92 |
| CHEMBL417737 | — | — | 1 | 4.92 |
| CHEMBL416876 | — | — | 1 | - |
| CHEMBL292339 | — | — | 1 | - |
| CHEMBL432526 | — | — | 1 | - |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | - |
| CHEMBL291886 | — | — | 1 | - |
| CHEMBL305150 | — | — | 1 | - |
| CHEMBL434213 | — | — | 1 | - |
| CHEMBL63222 | — | — | 1 | - |
| CHEMBL65242 | — | — | 1 | - |
| CHEMBL593 | DELAVIRDINE | 4.0 | 1 | - |
| CHEMBL304914 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39999 | TROVIRDINE | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL295585 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL294743 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL302866 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL417737 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL416876 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL292339 | — | Ki | - | nM | - | |
| CHEMBL432526 | — | Ki | - | nM | - | |
| CHEMBL57 | NEVIRAPINE | Ki | - | nM | - | |
| CHEMBL291886 | — | Ki | - | nM | - | |
| CHEMBL305150 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL434213 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL63222 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL65242 | — | Ki | - | nM | - | |
| CHEMBL593 | DELAVIRDINE | Ki | - | nM | - | |
| CHEMBL304914 | — | Ki | > | 100000.0 | nM | - |