Assay Detail
Functional
CHEMBL802289
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TNF and IL-1 induced IL-6 production in human chondro-sarcoma SW 1353 cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW1353 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
1-Phenyl-5-pyrazolyl ureas: potent and selective p38 kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.88 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64041 | — | — | 1 | 7.64 |
| CHEMBL441793 | — | — | 1 | 7.60 |
| CHEMBL64040 | — | — | 1 | 7.38 |
| CHEMBL291835 | — | — | 1 | 7.31 |
| CHEMBL10 | SB-203580 | — | 1 | 7.30 |
| CHEMBL64031 | — | — | 1 | 7.22 |
| CHEMBL418657 | — | — | 1 | 7.17 |
| CHEMBL303562 | — | — | 1 | 6.85 |
| CHEMBL62943 | — | — | 1 | 6.83 |
| CHEMBL64192 | — | — | 1 | 6.68 |
| CHEMBL65073 | — | — | 1 | 6.49 |
| CHEMBL41653 | — | — | 1 | 6.09 |
| CHEMBL303798 | — | — | 1 | 6.04 |
| CHEMBL291826 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64041 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL441793 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL64040 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL291835 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL10 | SB-203580 | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL64031 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL418657 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL303562 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL62943 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL64192 | — | IC50 | = | 209.0 | nM | 6.68 |
| CHEMBL65073 | — | IC50 | = | 324.0 | nM | 6.49 |
| CHEMBL41653 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL303798 | — | IC50 | = | 912.0 | nM | 6.04 |
| CHEMBL291826 | — | IC50 | = | 2000.0 | nM | 5.70 |