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Assay Detail

CHEMBL802338

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory concentration against Human pancreatic Serine protease chymotrypsin
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Chymotrypsin-C (CHEMBL2386)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

P1 Phenethyl peptide boronic acid inhibitors of HCV NS3 protease.
Priestley ES, De Lucca I, Ghavimi B, Erickson-Viitanen S, Decicco CP.
Bioorg Med Chem Lett (2002) 12 : 3199 -3202
PubMed 12372533 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 6.36 7.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL107656 1 7.30
CHEMBL320814 1 7.19
CHEMBL108189 1 7.16
CHEMBL109434 1 7.12
CHEMBL322933 1 6.55
CHEMBL322110 1 6.52
CHEMBL432978 1 6.42
CHEMBL111765 1 6.38
CHEMBL419567 1 5.72
CHEMBL263941 1 5.68
CHEMBL431246 1 5.43
CHEMBL107869 1 4.80
CHEMBL419918 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL107656 IC50 = 50.0 nM 7.30
CHEMBL320814 IC50 = 65.0 nM 7.19
CHEMBL108189 IC50 = 70.0 nM 7.16
CHEMBL109434 IC50 = 75.0 nM 7.12
CHEMBL322933 IC50 = 280.0 nM 6.55
CHEMBL322110 IC50 = 300.0 nM 6.52
CHEMBL432978 IC50 = 380.0 nM 6.42
CHEMBL111765 IC50 = 420.0 nM 6.38
CHEMBL419567 IC50 = 1900.0 nM 5.72
CHEMBL263941 IC50 = 2100.0 nM 5.68
CHEMBL431246 IC50 = 3700.0 nM 5.43
CHEMBL107869 IC50 = 16000.0 nM 4.80
CHEMBL419918 IC50 > 60000.0 nM -