Assay Detail
Binding
CHEMBL802398
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Antiviral activity was evaluated by Reverse transcriptase activity in cells acutely infected with HIV-1
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
6-N-Acyltriciribine analogues: structure-activity relationship between acyl carbon chain length and activity against HIV-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.43 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL611850 | — | — | 1 | 7.00 |
| CHEMBL607723 | — | — | 1 | 6.60 |
| CHEMBL607724 | — | — | 1 | 6.10 |
| CHEMBL611243 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL611850 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL607723 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL607724 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL611243 | — | IC50 | = | 1000.0 | nM | 6.00 |