Assay Detail
Binding
CHEMBL802401
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Compound concentration required to inhibit the HIV-1 recombinant Reverse transcriptase (rRT) activity by 50%.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Dihydro(alkylthio)(naphthylmethyl)oxopyrimidines: novel non-nucleoside reverse transcriptase inhibitors of the S-DABO series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.02 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.57 |
| CHEMBL284241 | — | — | 1 | 6.05 |
| CHEMBL290125 | — | — | 1 | 5.13 |
| CHEMBL417311 | — | — | 1 | 5.09 |
| CHEMBL33311 | — | — | 1 | 4.65 |
| CHEMBL287025 | — | — | 1 | 4.53 |
| CHEMBL32690 | — | — | 1 | 4.48 |
| CHEMBL286313 | — | — | 1 | 4.35 |
| CHEMBL36019 | — | — | 1 | 4.31 |
| CHEMBL34996 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL57 | NEVIRAPINE | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL284241 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL290125 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL417311 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL33311 | — | IC50 | = | 22500.0 | nM | 4.65 |
| CHEMBL287025 | — | IC50 | = | 29700.0 | nM | 4.53 |
| CHEMBL32690 | — | IC50 | = | 33100.0 | nM | 4.48 |
| CHEMBL286313 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL36019 | — | IC50 | = | 48700.0 | nM | 4.31 |
| CHEMBL34996 | — | IC50 | > | 100000.0 | nM | - |