Assay Detail
Binding
CHEMBL802406
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against HIV-1 recombinant reverse transcriptase.
26
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Structure-based design, synthesis, and biological evaluation of conformationally restricted novel 2-alkylthio-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.74 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL236161 | — | — | 3 | 8.30 |
| CHEMBL85947 | — | — | 1 | 7.72 |
| CHEMBL85946 | — | — | 1 | 7.70 |
| CHEMBL310803 | — | — | 1 | 7.70 |
| CHEMBL35033 | EMIVIRINE | 2.0 | 1 | 7.40 |
| CHEMBL309674 | — | — | 1 | 7.30 |
| CHEMBL83140 | — | — | 1 | 7.30 |
| CHEMBL87393 | — | — | 1 | 7.30 |
| CHEMBL87235 | — | — | 1 | 7.30 |
| CHEMBL87451 | — | — | 1 | 7.30 |
| CHEMBL309899 | — | — | 1 | 7.10 |
| CHEMBL312874 | — | — | 1 | 7.10 |
| CHEMBL83401 | — | — | 1 | 6.70 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.52 |
| CHEMBL86015 | — | — | 1 | 6.40 |
| CHEMBL314572 | — | — | 1 | 6.10 |
| CHEMBL314925 | — | — | 1 | 5.85 |
| CHEMBL315287 | — | — | 1 | 5.68 |
| CHEMBL87569 | — | — | 1 | 5.64 |
| CHEMBL85368 | — | — | 1 | 5.64 |
| CHEMBL85949 | — | — | 1 | 5.58 |
| CHEMBL86062 | — | — | 1 | 5.43 |
| CHEMBL86289 | — | — | 1 | 5.24 |
| CHEMBL87637 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL236161 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL236161 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL85947 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL310803 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL85946 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL35033 | EMIVIRINE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL309674 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL83140 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL87235 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL87393 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL87451 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL309899 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL312874 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL83401 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL86015 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL314572 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL236161 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL314925 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL315287 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL87569 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL85368 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL85949 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL86062 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL86289 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL87637 | — | IC50 | > | 10000.0 | nM | - |