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Assay Detail

CHEMBL802418

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against human immunodeficiency virus (HIV) - 1 reverse transcriptase with rCdG as the template primer
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247)
Type SINGLE PROTEIN
Organism Human immunodeficiency virus 1

Publication

New alkenyldiarylmethanes with enhanced potencies as anti-HIV agents which act as non-nucleoside reverse transcriptase inhibitors.
Cushman M, Casimiro-Garcia A, Hejchman E, Ruell JA, Huang M, Schaeffer CA, Williamson K, Rice WG, Buckheit RW.
J Med Chem (1998) 41 : 2076 -2089
PubMed 9622549 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 4.99 6.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL294840 1 6.52
CHEMBL58542 1 6.42
CHEMBL63515 1 5.70
CHEMBL63497 1 5.50
CHEMBL63150 1 5.44
CHEMBL63982 1 5.25
CHEMBL305535 1 4.96
CHEMBL63680 1 4.80
CHEMBL304269 1 4.58
CHEMBL65776 1 4.50
CHEMBL63394 1 4.20
CHEMBL418686 1 4.03
CHEMBL63229 1 4.02
CHEMBL63988 1 4.00
CHEMBL65753 1 -
CHEMBL65019 1 -
CHEMBL63567 1 -
CHEMBL63920 1 -
CHEMBL63900 1 -
CHEMBL67896 1 -
CHEMBL63505 1 -
CHEMBL63872 1 -
CHEMBL63473 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL294840 IC50 = 300.0 nM 6.52
CHEMBL58542 IC50 = 380.0 nM 6.42
CHEMBL63515 IC50 = 2000.0 nM 5.70
CHEMBL63497 IC50 = 3200.0 nM 5.50
CHEMBL63150 IC50 = 3600.0 nM 5.44
CHEMBL63982 IC50 = 5600.0 nM 5.25
CHEMBL305535 IC50 = 11000.0 nM 4.96
CHEMBL63680 IC50 = 16000.0 nM 4.80
CHEMBL304269 IC50 = 26000.0 nM 4.58
CHEMBL65776 IC50 = 31600.0 nM 4.50
CHEMBL63394 IC50 = 63000.0 nM 4.20
CHEMBL418686 IC50 = 94000.0 nM 4.03
CHEMBL63229 IC50 = 96000.0 nM 4.02
CHEMBL63988 IC50 = 100000.0 nM 4.00
CHEMBL65753 IC50 > 100000.0 nM -
CHEMBL65019 IC50 > 100000.0 nM -
CHEMBL63567 IC50 > 100000.0 nM -
CHEMBL63920 IC50 > 100000.0 nM -
CHEMBL63900 IC50 > 100000.0 nM -
CHEMBL67896 IC50 > 100000.0 nM -
CHEMBL63505 IC50 > 100000.0 nM -
CHEMBL63872 IC50 > 100000.0 nM -
CHEMBL63473 IC50 > 100000.0 nM -