Assay Detail

CHEMBL802548

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Binding

Inhibitory concentration against wild-type reverse transcriptase of HIV-1

ChEMBL ↗

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Target

Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗

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Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Human immunodeficiency virus type 1 reverse transcriptase

CHEMBL247

Anchored from Assay target.

Protein identity Human immunodeficiency virus type 1 reverse transcriptase

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Human immunodeficiency virus 1
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗

Type	SINGLE PROTEIN
Organism	Human immunodeficiency virus 1

Publication

Novel benzophenones as non-nucleoside reverse transcriptase inhibitors of HIV-1.

Chan JH, Freeman GA, Tidwell JH, Romines KR, Schaller LT, Cowan JR, Gonzales SS, Lowell GS, Andrews CW, Reynolds DJ, St Clair M, Hazen RJ, Ferris RG, Creech KL, Roberts GB, Short SA, Weaver K, Koszalka GW, Boone LR.
J Med Chem (2004) 47 : 1175 -1182
PubMed 14971897 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	3	7.81	9.12

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL223228	EFAVIRENZ	4.0	1	9.12
CHEMBL593	DELAVIRDINE	4.0	1	7.68
CHEMBL57	NEVIRAPINE	4.0	1	6.64

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL223228	EFAVIRENZ	IC50	=	0.75	nM	9.12
CHEMBL593	DELAVIRDINE	IC50	=	21.0	nM	7.68
CHEMBL57	NEVIRAPINE	IC50	=	230.0	nM	6.64