Assay Detail
Binding
CHEMBL802592
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Inhibitory activity against HIV-1 Mutant Reverse transcriptase P236L
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 8. 8-Aryloxymethyl- and 8-arylthiomethyldipyridodiazepinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.54 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL103386 | — | — | 1 | 7.22 |
| CHEMBL102034 | — | — | 1 | 6.89 |
| CHEMBL103946 | — | — | 1 | 6.80 |
| CHEMBL99624 | — | — | 1 | 6.75 |
| CHEMBL319277 | — | — | 1 | 6.68 |
| CHEMBL99793 | — | — | 1 | 6.66 |
| CHEMBL102166 | — | — | 1 | 6.52 |
| CHEMBL320663 | — | — | 1 | 6.29 |
| CHEMBL321544 | — | — | 1 | 6.26 |
| CHEMBL102192 | — | — | 1 | 6.08 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 5.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL103386 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL102034 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL103946 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL99624 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL319277 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL99793 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL102166 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL320663 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL321544 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL102192 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 1480.0 | nM | 5.83 |