Assay Detail
Binding
CHEMBL802594
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Inhibitory activity against HIV-1 Mutant Reverse transcriptase V106A
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 8. 8-Aryloxymethyl- and 8-arylthiomethyldipyridodiazepinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.06 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL319277 | — | — | 1 | 8.00 |
| CHEMBL102166 | — | — | 1 | 8.00 |
| CHEMBL321544 | — | — | 1 | 7.52 |
| CHEMBL103386 | — | — | 1 | 7.40 |
| CHEMBL102034 | — | — | 1 | 7.30 |
| CHEMBL102192 | — | — | 1 | 6.92 |
| CHEMBL99624 | — | — | 1 | 6.92 |
| CHEMBL320663 | — | — | 1 | 6.10 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 5.41 |
| CHEMBL99793 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL319277 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL102166 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL321544 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL103386 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL102034 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL102192 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL99624 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL320663 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 3930.0 | nM | 5.41 |
| CHEMBL99793 | — | IC50 | = | - | nM | - |