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Assay Detail

CHEMBL802758

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Binding
In vitro inhibition of recombinant reverse transcriptase (WT) of HIV-1 IIIB
ChEMBL ↗
39
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Human immunodeficiency virus 1
Confidence 9 — Direct single protein target
Curated By Expert

Target

Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗
Type SINGLE PROTEIN
Organism Human immunodeficiency virus 1

Publication

Targeting delavirdine/atevirdine resistant HIV-1: identification of (alkylamino)piperidine-containing bis(heteroaryl)piperazines as broad spectrum HIV-1 reverse transcriptase inhibitors.
Romero DL, Olmsted RA, Poel TJ, Morge RA, Biles C, Keiser BJ, Kopta LA, Friis JM, Hosley JD, Stefanski KJ, Wishka DG, Evans DB, Morris J, Stehle RG, Sharma SK, Yagi Y, Voorman RL, Adams WJ, Tarpley WG, Thomas RC.
J Med Chem (1996) 39 : 3769 -3789
PubMed 8809165 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 39 6.44 7.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL122343 — — 1 7.05
CHEMBL126107 — — 1 6.89
CHEMBL331911 — — 1 6.85
CHEMBL262633 — — 1 6.85
CHEMBL125715 — — 1 6.82
CHEMBL125203 — — 1 6.80
CHEMBL331790 — — 1 6.77
CHEMBL125437 — — 1 6.75
CHEMBL339279 — — 1 6.72
CHEMBL125478 — — 1 6.66
CHEMBL125019 — — 1 6.64
CHEMBL436392 — — 1 6.64
CHEMBL340822 — — 1 6.62
CHEMBL125112 — — 1 6.62
CHEMBL331330 — — 1 6.60
CHEMBL929 DELAVIRDINE MESYLATE 4.0 2 6.58
CHEMBL339406 — — 1 6.52
CHEMBL124610 — — 1 6.46
CHEMBL121827 — — 1 6.44
CHEMBL340556 — — 1 6.42
CHEMBL332675 — — 1 6.42
CHEMBL340453 — — 1 6.40
CHEMBL122460 — — 1 6.35
CHEMBL127283 — — 1 6.34
CHEMBL127456 — — 1 6.34
CHEMBL125324 — — 1 6.32
CHEMBL124338 — — 1 6.30
CHEMBL330990 — — 1 6.28
CHEMBL340193 — — 1 6.28
CHEMBL421246 — — 1 6.16

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL122343 — IC50 = 90.0 nM 7.05
CHEMBL126107 — IC50 = 130.0 nM 6.89
CHEMBL331911 — IC50 = 140.0 nM 6.85
CHEMBL262633 — IC50 = 140.0 nM 6.85
CHEMBL125715 — IC50 = 150.0 nM 6.82
CHEMBL125203 — IC50 = 160.0 nM 6.80
CHEMBL331790 — IC50 = 170.0 nM 6.77
CHEMBL125437 — IC50 = 180.0 nM 6.75
CHEMBL339279 — IC50 = 190.0 nM 6.72
CHEMBL125478 — IC50 = 220.0 nM 6.66
CHEMBL125019 — IC50 = 230.0 nM 6.64
CHEMBL436392 — IC50 = 230.0 nM 6.64
CHEMBL125112 — IC50 = 240.0 nM 6.62
CHEMBL340822 — IC50 = 240.0 nM 6.62
CHEMBL331330 — IC50 = 250.0 nM 6.60
CHEMBL929 DELAVIRDINE MESYLATE IC50 = 260.0 nM 6.58
CHEMBL339406 — IC50 = 300.0 nM 6.52
CHEMBL124610 — IC50 = 350.0 nM 6.46
CHEMBL121827 — IC50 = 360.0 nM 6.44
CHEMBL340556 — IC50 = 380.0 nM 6.42
CHEMBL332675 — IC50 = 380.0 nM 6.42
CHEMBL340453 — IC50 = 400.0 nM 6.40
CHEMBL122460 — IC50 = 450.0 nM 6.35
CHEMBL127283 — IC50 = 460.0 nM 6.34
CHEMBL127456 — IC50 = 460.0 nM 6.34
CHEMBL125324 — IC50 = 480.0 nM 6.32
CHEMBL124338 — IC50 = 500.0 nM 6.30
CHEMBL330990 — IC50 = 530.0 nM 6.28
CHEMBL340193 — IC50 = 520.0 nM 6.28
CHEMBL421246 — IC50 = 700.0 nM 6.16
CHEMBL123478 — IC50 = 730.0 nM 6.14
CHEMBL121881 — IC50 = 740.0 nM 6.13
CHEMBL125896 — IC50 = 790.0 nM 6.10
CHEMBL268871 L-697661 IC50 = 800.0 nM 6.10
CHEMBL331684 — IC50 = 830.0 nM 6.08
CHEMBL340403 — IC50 = 1020.0 nM 5.99
CHEMBL7264 ATEVIRDINE SULPHATE IC50 = 2300.0 nM 5.64
CHEMBL57 NEVIRAPINE IC50 = 3100.0 nM 5.51
CHEMBL929 DELAVIRDINE MESYLATE IC50 > 10000.0 nM -