Assay Detail
Binding
CHEMBL802762
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In vitro inhibitory concentration against reverse transcriptase of HIV-1 (RT)
34
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and anti-HIV-1 activity of a series of imidazo[1,5-b]pyridazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 6.11 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL338099 | — | — | 1 | 9.22 |
| CHEMBL341350 | — | — | 1 | 7.30 |
| CHEMBL125446 | — | — | 1 | 7.10 |
| CHEMBL1203237 | — | — | 1 | 7.10 |
| CHEMBL434441 | — | — | 1 | 7.00 |
| CHEMBL125532 | — | — | 1 | 7.00 |
| CHEMBL121820 | — | — | 1 | 6.64 |
| CHEMBL341512 | — | — | 1 | 6.57 |
| CHEMBL125205 | — | — | 1 | 6.47 |
| CHEMBL125084 | — | — | 1 | 6.42 |
| CHEMBL127427 | — | — | 1 | 6.26 |
| CHEMBL340248 | — | — | 1 | 6.25 |
| CHEMBL435017 | — | — | 1 | 6.19 |
| CHEMBL1203236 | — | — | 1 | 6.19 |
| CHEMBL124248 | — | — | 1 | 6.08 |
| CHEMBL338415 | — | — | 1 | 5.89 |
| CHEMBL338339 | — | — | 2 | 5.89 |
| CHEMBL123514 | — | — | 1 | 5.70 |
| CHEMBL435216 | — | — | 1 | 5.64 |
| CHEMBL123202 | — | — | 1 | 5.60 |
| CHEMBL126216 | — | — | 1 | 5.58 |
| CHEMBL126811 | — | — | 1 | 5.52 |
| CHEMBL338823 | — | — | 1 | 5.52 |
| CHEMBL124271 | — | — | 1 | 5.47 |
| CHEMBL338302 | — | — | 1 | 5.47 |
| CHEMBL332351 | — | — | 1 | 5.41 |
| CHEMBL124246 | — | — | 1 | 5.32 |
| CHEMBL262415 | — | — | 1 | 5.17 |
| CHEMBL341238 | — | — | 1 | 4.85 |
| CHEMBL123839 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL338099 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL341350 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL125446 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1203237 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL434441 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL125532 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL121820 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL341512 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL125205 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL125084 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL127427 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL340248 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL435017 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL1203236 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL124248 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL338415 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL338339 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL338339 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL123514 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL435216 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL123202 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL126216 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL126811 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL338823 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL124271 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL338302 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL332351 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL124246 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL262415 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL341238 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL123839 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL434047 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL125806 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL333863 | — | IC50 | > | 100000.0 | nM | - |