Assay Detail
Binding
CHEMBL802840
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Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slices
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Binary drugs: conjugates of purines and a peptide that bind to both adenosine and substance P receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.86 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL235363 | SUBSTANCE P | 1.0 | 1 | 8.96 |
| CHEMBL2371916 | — | — | 1 | 6.75 |
| CHEMBL3143946 | — | — | 1 | 6.52 |
| CHEMBL2372339 | — | — | 1 | 6.35 |
| CHEMBL3144091 | — | — | 1 | 5.70 |
| CHEMBL606297 | — | — | 1 | - |
| CHEMBL3143947 | — | — | 1 | - |
| CHEMBL2372353 | — | — | 1 | - |
| CHEMBL2372385 | — | — | 1 | - |
| CHEMBL39503 | — | — | 1 | - |
| CHEMBL37306 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL235363 | SUBSTANCE P | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL2371916 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL3143946 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL2372339 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL3144091 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL606297 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3143947 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2372353 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2372385 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL39503 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL37306 | — | Ki | > | 10000.0 | nM | - |