Assay Detail
Binding
CHEMBL802882
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Compound was tested for inhibition of HIV-1 WT reverse transcriptase using poly(rA)300:oligo(dT)10 as substrate
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Targeting delavirdine/atevirdine resistant HIV-1: identification of (alkylamino)piperidine-containing bis(heteroaryl)piperazines as broad spectrum HIV-1 reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.91 | 6.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL338435 | — | — | 1 | 6.07 |
| CHEMBL338979 | — | — | 1 | 5.86 |
| CHEMBL331912 | — | — | 1 | 5.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL338435 | — | Ki | = | 853.0 | nM | 6.07 |
| CHEMBL338979 | — | Ki | = | 1380.0 | nM | 5.86 |
| CHEMBL331912 | — | Ki | = | 1640.0 | nM | 5.79 |