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Assay Detail

CHEMBL802897

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of forskolin-stimulated glycogenolysis in SK-HEP-1 cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Indole-2-carboxamide inhibitors of human liver glycogen phosphorylase.
Hoover DJ, Lefkowitz-Snow S, Burgess-Henry JL, Martin WH, Armento SJ, Stock IA, McPherson RK, Genereux PE, Gibbs EM, Treadway JL.
J Med Chem (1998) 41 : 2934 -2938
PubMed 9685232 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.37 5.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL318910 1 5.85
CHEMBL319136 1 5.82
CHEMBL430503 1 5.72
CHEMBL99889 1 5.72
CHEMBL327504 1 5.64
CHEMBL329493 1 5.48
CHEMBL317410 1 5.29
CHEMBL99379 1 5.28
CHEMBL99597 1 5.21
CHEMBL319165 1 5.11
CHEMBL98891 1 4.92
CHEMBL316598 1 4.92
CHEMBL319854 1 4.89
CHEMBL319152 1 -
CHEMBL317861 1 -
CHEMBL431463 1 -
CHEMBL100872 1 -
CHEMBL99556 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL318910 IC50 = 1400.0 nM 5.85
CHEMBL319136 IC50 = 1500.0 nM 5.82
CHEMBL430503 IC50 = 1900.0 nM 5.72
CHEMBL99889 IC50 = 1900.0 nM 5.72
CHEMBL327504 IC50 = 2300.0 nM 5.64
CHEMBL329493 IC50 = 3300.0 nM 5.48
CHEMBL317410 IC50 = 5100.0 nM 5.29
CHEMBL99379 IC50 = 5200.0 nM 5.28
CHEMBL99597 IC50 = 6200.0 nM 5.21
CHEMBL319165 IC50 = 7800.0 nM 5.11
CHEMBL98891 IC50 = 12000.0 nM 4.92
CHEMBL316598 IC50 = 12000.0 nM 4.92
CHEMBL319854 IC50 = 13000.0 nM 4.89
CHEMBL319152 IC50 > 30000.0 nM -
CHEMBL317861 IC50 > 30000.0 nM -
CHEMBL431463 IC50 > 30000.0 nM -
CHEMBL100872 IC50 > 30000.0 nM -
CHEMBL99556 IC50 > 30000.0 nM -