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Assay Detail

CHEMBL802902

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Compound was tested for its cytotoxicity against human malignant melanoma cell line SK-MEL
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SK-MEL
Confidence 1 — Organism
Curated By Intermediate

Target

SK-MEL (CHEMBL614914)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and evaluation of potential complement inhibitory semisynthetic analogs of oleanolic acid.
Assefa H, Nimrod A, Walker L, Sindelar R.
Bioorg Med Chem Lett (1999) 9 : 1889 -1894
PubMed 10450948 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 4.22 4.51

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL470029 OLEANONIC ACID 1 4.51
CHEMBL269277 BETULINIC ACID 1.0 1 4.46
CHEMBL57052 1 4.16
CHEMBL293311 1 4.11
CHEMBL298623 1 4.07
CHEMBL55273 1 4.03
CHEMBL487412 METHYL OLEANOLATE 1 -
CHEMBL60687 1 -
CHEMBL366695 1 -
CHEMBL457064 1 -
CHEMBL56287 1 -
CHEMBL168 OLEANOLIC_ACID 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL470029 OLEANONIC ACID IC50 = 31000.0 nM 4.51
CHEMBL269277 BETULINIC ACID IC50 = 35000.0 nM 4.46
CHEMBL57052 IC50 = 70000.0 nM 4.16
CHEMBL293311 IC50 = 77000.0 nM 4.11
CHEMBL298623 IC50 = 86000.0 nM 4.07
CHEMBL55273 IC50 = 93000.0 nM 4.03
CHEMBL487412 METHYL OLEANOLATE IC50 = 103000.0 nM -
CHEMBL60687 IC50 = 105000.0 nM -
CHEMBL366695 IC50 = 131000.0 nM -
CHEMBL457064 IC50 = 115000.0 nM -
CHEMBL56287 IC50 = 127000.0 nM -
CHEMBL168 OLEANOLIC_ACID IC50 = 112000.0 nM -