Assay Detail
Binding
CHEMBL802970
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Inhibition of influenza A sialidase (neuraminidase)
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus (strain: A/PR/8/34) |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Neuraminidase (CHEMBL2051) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) |
Publication
Novel inhibitors of influenza sialidases related to GG167 structure-activity, crystallographic and Molecular dynamics studies with 4H-pyran-2-carboxylic acid 6-carboxamides
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.30 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98262 | — | — | 1 | 9.00 |
| CHEMBL433269 | — | — | 1 | 8.70 |
| CHEMBL99224 | — | — | 1 | 8.52 |
| CHEMBL98906 | — | — | 1 | 8.52 |
| CHEMBL295490 | — | — | 1 | 8.52 |
| CHEMBL317645 | — | — | 1 | 8.52 |
| CHEMBL101842 | — | — | 1 | 8.40 |
| CHEMBL300461 | — | — | 1 | 8.40 |
| CHEMBL318452 | — | — | 1 | 8.30 |
| CHEMBL73669 | — | — | 1 | 8.30 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 8.30 |
| CHEMBL317571 | — | — | 1 | 8.30 |
| CHEMBL321962 | — | — | 1 | 7.80 |
| CHEMBL430869 | — | — | 1 | 7.64 |
| CHEMBL100991 | — | — | 1 | 7.60 |
| CHEMBL50254 | — | — | 1 | 6.75 |
| CHEMBL52270 | — | — | 1 | 6.52 |
| CHEMBL98838 | — | — | 1 | 6.50 |
| CHEMBL419710 | — | — | 1 | 6.35 |
| CHEMBL54149 | — | — | 1 | 6.30 |
| CHEMBL100677 | — | — | 1 | 5.62 |
| CHEMBL319143 | — | — | 1 | 5.16 |
| CHEMBL71078 | — | — | 1 | 4.92 |
| CHEMBL318671 | — | — | 1 | 4.89 |
| CHEMBL51451 | — | — | 1 | 4.72 |
| CHEMBL100637 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98262 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL433269 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL99224 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL98906 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL295490 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL317645 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL101842 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL300461 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL318452 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL73669 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL317571 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL321962 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL430869 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL100991 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL50254 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL52270 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL98838 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL419710 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL54149 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL100677 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL319143 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL71078 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL318671 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL51451 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL100637 | — | IC50 | = | 190000.0 | nM | - |