Assay Detail
Binding
CHEMBL802971
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Compound was tested for inhibitory concentration against Influenza sialidase type A
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuraminidase (CHEMBL2051) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) |
Publication
Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 2. Crystallographic and molecular modeling study of complexes of 4-amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.43 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL73669 | — | — | 1 | 8.70 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 8.30 |
| CHEMBL317571 | — | — | 1 | 8.30 |
| CHEMBL165651 | — | — | 1 | 7.85 |
| CHEMBL98838 | — | — | 1 | 6.50 |
| CHEMBL71078 | — | — | 1 | 4.92 |
| CHEMBL165084 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL73669 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL317571 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL165651 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL98838 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL71078 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL165084 | — | IC50 | = | 1000000.0 | nM | - |