Assay Detail
Binding
CHEMBL802972
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Inhibition of influenza sialidase was determined by measuring the ability to inhibit the hydrolysis of MUN by A/Aichi virus grown in hen eggs
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuraminidase (CHEMBL2051) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) |
Publication
Novel inhibitors of influenza sialidase related to GG167 Synthesis of 4-amino and guanidino-4H-pyran-2-carboxylic acid-6-propylamides; selective inhibitors of influenza a virus sialidase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.20 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL433269 | — | — | 1 | 8.70 |
| CHEMBL300461 | — | — | 1 | 8.40 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 8.30 |
| CHEMBL295490 | — | — | 1 | 7.92 |
| CHEMBL50254 | — | — | 1 | 6.75 |
| CHEMBL52270 | — | — | 1 | 6.50 |
| CHEMBL54149 | — | — | 1 | 6.30 |
| CHEMBL51451 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL433269 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL300461 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL295490 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL50254 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL52270 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL54149 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL51451 | — | IC50 | = | 19000.0 | nM | 4.72 |