Assay Detail
Binding
CHEMBL802973
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Inhibitory activity against influenza A sialidase (Aichi)
18
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus (strain: A/PR/8/34) |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Neuraminidase (CHEMBL2051) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) |
Publication
Sialidase inhibitors related to zanamivir. Further SAR studies of 4-amino-4H-pyran-2-carboxylic acid-6-propylamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.50 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL350298 | — | — | 1 | 9.52 |
| CHEMBL349042 | — | — | 1 | 9.15 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 8.70 |
| CHEMBL348066 | — | — | 1 | 8.52 |
| CHEMBL73669 | — | — | 2 | 8.52 |
| CHEMBL346767 | — | — | 1 | 8.30 |
| CHEMBL162413 | — | — | 1 | 8.15 |
| CHEMBL422357 | — | — | 1 | 8.15 |
| CHEMBL295490 | — | — | 1 | 7.92 |
| CHEMBL350837 | — | — | 1 | 7.77 |
| CHEMBL350474 | — | — | 1 | 7.30 |
| CHEMBL422026 | — | — | 1 | 6.85 |
| CHEMBL161629 | — | — | 1 | 6.62 |
| CHEMBL422016 | — | — | 1 | 6.38 |
| CHEMBL348995 | — | — | 1 | 5.52 |
| CHEMBL346548 | — | — | 1 | 4.77 |
| CHEMBL353573 | — | — | 1 | 4.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL350298 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL349042 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL73669 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL348066 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL73669 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL346767 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL162413 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL422357 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL295490 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL350837 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL350474 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL422026 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL161629 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL422016 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL348995 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL346548 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL353573 | — | IC50 | = | 43000.0 | nM | 4.37 |