Assay Detail
Binding
CHEMBL802982
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Inhibition of influenza B sialidase (neuraminidase)
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza B virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Neuraminidase (CHEMBL3377) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza B virus (strain B/Lee/1940) |
Publication
Novel inhibitors of influenza sialidases related to GG167 structure-activity, crystallographic and Molecular dynamics studies with 4H-pyran-2-carboxylic acid 6-carboxamides
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.38 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 8.40 |
| CHEMBL52270 | — | — | 1 | 6.40 |
| CHEMBL99224 | — | — | 1 | 6.40 |
| CHEMBL317645 | — | — | 1 | 6.40 |
| CHEMBL433269 | — | — | 1 | 6.30 |
| CHEMBL98262 | — | — | 1 | 6.30 |
| CHEMBL318452 | — | — | 1 | 6.10 |
| CHEMBL101842 | — | — | 1 | 6.00 |
| CHEMBL295490 | — | — | 1 | 5.70 |
| CHEMBL73669 | — | — | 1 | 5.70 |
| CHEMBL98906 | — | — | 1 | 5.64 |
| CHEMBL54149 | — | — | 1 | 5.36 |
| CHEMBL300461 | — | — | 1 | 5.35 |
| CHEMBL317571 | — | — | 1 | 5.10 |
| CHEMBL100991 | — | — | 1 | 4.96 |
| CHEMBL50254 | — | — | 1 | 4.64 |
| CHEMBL321962 | — | — | 1 | 4.51 |
| CHEMBL430869 | — | — | 1 | 4.43 |
| CHEMBL318671 | — | — | 1 | 4.39 |
| CHEMBL51451 | — | — | 1 | 4.30 |
| CHEMBL98838 | — | — | 1 | 4.29 |
| CHEMBL100677 | — | — | 1 | 4.21 |
| CHEMBL71078 | — | — | 1 | 4.17 |
| CHEMBL100637 | — | — | 1 | 4.10 |
| CHEMBL419710 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL52270 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL99224 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL317645 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL433269 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL98262 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL318452 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL101842 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL295490 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL73669 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL98906 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL54149 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL300461 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL317571 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL100991 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL50254 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL321962 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL430869 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL318671 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL51451 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL98838 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL100677 | — | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL71078 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL100637 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL419710 | — | IC50 | > | 430000.0 | nM | - |