Assay Detail
Binding
CHEMBL802984
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Inhibition of influenza sialidase was determined by measuring the ability to inhibit the hydrolysis of MUN by B Victoria virus grown in hen eggs
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza B virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuraminidase (CHEMBL3377) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza B virus (strain B/Lee/1940) |
Publication
Novel inhibitors of influenza sialidase related to GG167 Synthesis of 4-amino and guanidino-4H-pyran-2-carboxylic acid-6-propylamides; selective inhibitors of influenza a virus sialidase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.80 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 8.40 |
| CHEMBL52270 | — | — | 1 | 6.39 |
| CHEMBL433269 | — | — | 1 | 6.27 |
| CHEMBL295490 | — | — | 1 | 5.70 |
| CHEMBL54149 | — | — | 1 | 5.36 |
| CHEMBL300461 | — | — | 1 | 5.35 |
| CHEMBL50254 | — | — | 1 | 4.64 |
| CHEMBL51451 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL52270 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL433269 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL295490 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL54149 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL300461 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL50254 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL51451 | — | IC50 | = | 50000.0 | nM | 4.30 |