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Assay Detail

CHEMBL802985

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Binding
Inhibitory activity against influenza B sialidase (Victoria)
18
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Influenza B virus
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Neuraminidase (CHEMBL3377)
Type SINGLE PROTEIN
Organism Influenza B virus (strain B/Lee/1940)

Publication

Sialidase inhibitors related to zanamivir. Further SAR studies of 4-amino-4H-pyran-2-carboxylic acid-6-propylamides.
Wyatt PG, Coomber BA, Evans DN, Jack TI, Fulton HE, Wonacott AJ, Colman P, Varghese J.
Bioorg Med Chem Lett (2001) 11 : 669 -673
PubMed 11266166 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.49 8.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL222813 ZANAMIVIR 4.0 1 8.40
CHEMBL348066 1 7.00
CHEMBL350298 1 6.70
CHEMBL295490 1 5.70
CHEMBL73669 2 5.52
CHEMBL422016 1 5.35
CHEMBL349042 1 5.22
CHEMBL346767 1 5.16
CHEMBL422026 1 5.13
CHEMBL422357 1 4.85
CHEMBL162413 1 4.29
CHEMBL350474 1 4.05
CHEMBL348995 1 4.04
CHEMBL161629 1 -
CHEMBL353573 1 -
CHEMBL350837 1 -
CHEMBL346548 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL222813 ZANAMIVIR IC50 = 4.0 nM 8.40
CHEMBL348066 IC50 = 100.0 nM 7.00
CHEMBL350298 IC50 = 200.0 nM 6.70
CHEMBL295490 IC50 = 2000.0 nM 5.70
CHEMBL73669 IC50 = 3000.0 nM 5.52
CHEMBL73669 IC50 = 3600.0 nM 5.44
CHEMBL422016 IC50 = 4500.0 nM 5.35
CHEMBL349042 IC50 = 6000.0 nM 5.22
CHEMBL346767 IC50 = 7000.0 nM 5.16
CHEMBL422026 IC50 = 7400.0 nM 5.13
CHEMBL422357 IC50 = 14000.0 nM 4.85
CHEMBL162413 IC50 = 51000.0 nM 4.29
CHEMBL350474 IC50 = 90000.0 nM 4.05
CHEMBL348995 IC50 = 92000.0 nM 4.04
CHEMBL161629 IC50 = 140000.0 nM -
CHEMBL353573 IC50 > 500000.0 nM -
CHEMBL350837 IC50 > 400000.0 nM -
CHEMBL346548 IC50 > 540000.0 nM -