Assay Detail
Functional
CHEMBL802986
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Inhibitory activity against sialidase of influenza B
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza B virus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Sialidase inhibitors related to zanamivir: synthesis and biological evaluation of 4H-pyran 6-ether and ketone.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.36 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 8.40 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 7.50 |
| CHEMBL317645 | — | — | 1 | 6.44 |
| CHEMBL345674 | — | — | 1 | 6.33 |
| CHEMBL436422 | — | — | 1 | 5.13 |
| CHEMBL156342 | — | — | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL317645 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL345674 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL436422 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL156342 | — | IC50 | = | 42000.0 | nM | 4.38 |