Assay Detail
Binding
CHEMBL803150
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In vitro inhibitory activity against recombinant S-adenosyl-L-homocysteine hydrolase obtained from human placenta
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis of fluorinated cyclopentenyladenine as potent inhibitor of S-adenosylhomocysteine hydrolase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.62 | 6.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64718 | FLUORO-NEPLANOCIN A | — | 1 | 6.33 |
| CHEMBL8771 | NEOPLANOCIN A | — | 1 | 6.05 |
| CHEMBL299961 | — | — | 1 | 5.06 |
| CHEMBL63311 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64718 | FLUORO-NEPLANOCIN A | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL8771 | NEOPLANOCIN A | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL299961 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL63311 | — | IC50 | = | 8900.0 | nM | 5.05 |