Assay Detail
Functional
CHEMBL803233
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Dissociation constant (Kd) of renin inhibitor was determined over a temperature range of 8-37 degree by the fluorescence displacement assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Thermodynamics of the interaction of inhibitors with the binding site of recombinant human renin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 13 | 7.44 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2062123 | — | — | 1 | 8.89 |
| CHEMBL438100 | — | — | 1 | 8.77 |
| CHEMBL2062128 | — | — | 1 | 8.60 |
| CHEMBL2062122 | — | — | 1 | 8.27 |
| CHEMBL407670 | — | — | 1 | 8.10 |
| CHEMBL2062124 | — | — | 1 | 7.64 |
| CHEMBL3142167 | — | — | 1 | 7.54 |
| CHEMBL2062121 | — | — | 1 | 7.01 |
| CHEMBL2062129 | — | — | 1 | 6.69 |
| CHEMBL2062125 | — | — | 1 | 6.66 |
| CHEMBL2062126 | — | — | 1 | 6.43 |
| CHEMBL2028834 | — | — | 1 | 6.09 |
| CHEMBL2062127 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2062123 | — | Kd | = | 1.3 | nM | 8.89 |
| CHEMBL438100 | — | Kd | = | 1.7 | nM | 8.77 |
| CHEMBL2062128 | — | Kd | = | 2.5 | nM | 8.60 |
| CHEMBL2062122 | — | Kd | = | 5.4 | nM | 8.27 |
| CHEMBL407670 | — | Kd | = | 8.0 | nM | 8.10 |
| CHEMBL2062124 | — | Kd | = | 23.0 | nM | 7.64 |
| CHEMBL3142167 | — | Kd | = | 29.0 | nM | 7.54 |
| CHEMBL2062121 | — | Kd | = | 98.0 | nM | 7.01 |
| CHEMBL2062129 | — | Kd | = | 204.0 | nM | 6.69 |
| CHEMBL2062125 | — | Kd | = | 220.0 | nM | 6.66 |
| CHEMBL2062126 | — | Kd | = | 370.0 | nM | 6.43 |
| CHEMBL2028834 | — | Kd | = | 810.0 | nM | 6.09 |
| CHEMBL2062127 | — | Kd | = | 1000.0 | nM | 6.00 |