Assay Detail
Binding
CHEMBL803238
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Compound was tested for inhibition of human kidney renin
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Kidney |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A uniquely potent renin inhibitor and its unanticipated plasma binding component.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.98 | 10.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3144404 | — | — | 1 | 10.59 |
| CHEMBL3144405 | — | — | 1 | 10.19 |
| CHEMBL3144406 | — | — | 1 | 8.44 |
| CHEMBL40928 | — | — | 1 | 8.32 |
| CHEMBL424543 | — | — | 1 | 7.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3144404 | — | Ki | = | 0.026 | nM | 10.59 |
| CHEMBL3144405 | — | Ki | = | 0.064 | nM | 10.19 |
| CHEMBL3144406 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL40928 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL424543 | — | Ki | = | 43.0 | nM | 7.37 |