Assay Detail
Binding
CHEMBL803242
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of purified human kidney renin, radioimmunoassay using a synthetic tetradecapeptide renin substrate at 10e-9 M concentration
17
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Renin inhibitors. Statine-containing tetrapeptides with varied hydrophobic carboxy termini.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.53 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54411 | — | — | 1 | 10.40 |
| CHEMBL300498 | — | — | 2 | 9.70 |
| CHEMBL412656 | — | — | 1 | 8.22 |
| CHEMBL298510 | — | — | 2 | 7.89 |
| CHEMBL269752 | — | — | 1 | 7.77 |
| CHEMBL53112 | — | — | 3 | 7.70 |
| CHEMBL300442 | — | — | 1 | 7.44 |
| CHEMBL301129 | — | — | 1 | 7.30 |
| CHEMBL3085574 | — | — | 1 | 7.26 |
| CHEMBL54886 | — | — | 1 | 7.00 |
| CHEMBL53099 | — | — | 2 | 6.46 |
| CHEMBL297880 | — | — | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54411 | — | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL300498 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL412656 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL298510 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL269752 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL53112 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL300442 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL53112 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL300498 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL301129 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL3085574 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL53112 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL54886 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL298510 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL53099 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL297880 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL53099 | — | Ki | = | 1000.0 | nM | 6.00 |