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Assay Detail

CHEMBL803244

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Antihypertensive activity against human renin
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Renin (CHEMBL286)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Inhibition of the renin-angiotensin system. A new approach to the therapy of hypertension.
Ondetti MA, Cushman DW.
J Med Chem (1981) 24 : 355 -361
PubMed 6267277 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 15 6.56 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL331466 1 9.00
CHEMBL39538 1 8.92
CHEMBL1560 CAPTOPRIL 4.0 1 8.77
CHEMBL120658 1 7.00
CHEMBL296588 PEPSTATIN 2.0 1 7.00
CHEMBL123069 1 6.52
CHEMBL332513 1 6.22
CHEMBL216386 1 6.10
CHEMBL78780 1 6.10
CHEMBL384760 1 6.00
CHEMBL438636 1 5.70
CHEMBL331117 1 5.66
CHEMBL78805 1 5.60
CHEMBL267446 1 5.40
CHEMBL441371 1 4.38

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL331466 Ki = 1.0 nM 9.00
CHEMBL39538 Ki = 1.2 nM 8.92
CHEMBL1560 CAPTOPRIL Ki = 1.7 nM 8.77
CHEMBL120658 Ki = 100.0 nM 7.00
CHEMBL296588 PEPSTATIN Ki = 100.0 nM 7.00
CHEMBL123069 Ki = 300.0 nM 6.52
CHEMBL332513 Ki = 600.0 nM 6.22
CHEMBL216386 Ki = 800.0 nM 6.10
CHEMBL78780 Ki = 800.0 nM 6.10
CHEMBL384760 Ki = 1000.0 nM 6.00
CHEMBL438636 Ki = 2000.0 nM 5.70
CHEMBL331117 Ki = 2200.0 nM 5.66
CHEMBL78805 Ki = 2500.0 nM 5.60
CHEMBL267446 Ki = 4000.0 nM 5.40
CHEMBL441371 Ki = 42000.0 nM 4.38