Assay Detail
Functional
CHEMBL803331
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity against Retinoic acid receptor RXR-alpha expressed in CV-1 cell transcriptional activation assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CV-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of fluorinated RXR modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.15 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL110195 | — | — | 1 | 8.48 |
| CHEMBL325592 | — | — | 1 | 8.47 |
| CHEMBL92050 | — | — | 1 | 8.19 |
| CHEMBL111217 | — | — | 1 | 8.17 |
| CHEMBL107555 | — | — | 1 | 7.42 |
| CHEMBL107554 | — | — | 1 | 6.09 |
| CHEMBL326673 | — | — | 1 | 5.32 |
| CHEMBL110921 | — | — | 1 | 5.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL110195 | — | EC50 | = | 3.3 | nM | 8.48 |
| CHEMBL325592 | — | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL92050 | — | EC50 | = | 6.4 | nM | 8.19 |
| CHEMBL111217 | — | EC50 | = | 6.8 | nM | 8.17 |
| CHEMBL107555 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL107554 | — | EC50 | = | 805.8 | nM | 6.09 |
| CHEMBL326673 | — | EC50 | = | 4842.1 | nM | 5.32 |
| CHEMBL110921 | — | EC50 | = | 8712.8 | nM | 5.06 |