Assay Detail
Binding
CHEMBL803423
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Inhibitory activity against human plasma renin
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Plasma |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Piperidine-renin inhibitors compounds with improved physicochemical properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.36 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL430539 | — | — | 1 | 7.92 |
| CHEMBL32002 | — | — | 1 | 7.43 |
| CHEMBL285046 | — | — | 1 | 6.96 |
| CHEMBL285146 | — | — | 1 | 6.96 |
| CHEMBL285779 | — | — | 1 | 6.89 |
| CHEMBL31675 | — | — | 1 | 6.80 |
| CHEMBL30618 | — | — | 1 | 6.80 |
| CHEMBL31404 | — | — | 1 | 6.80 |
| CHEMBL31881 | — | — | 1 | 6.72 |
| CHEMBL283046 | — | — | 1 | 6.48 |
| CHEMBL287023 | — | — | 1 | 6.42 |
| CHEMBL286413 | — | — | 1 | 6.31 |
| CHEMBL265984 | — | — | 1 | 6.09 |
| CHEMBL31466 | — | — | 1 | 5.89 |
| CHEMBL281299 | — | — | 1 | 5.85 |
| CHEMBL284690 | — | — | 1 | 5.85 |
| CHEMBL31880 | — | — | 1 | 5.72 |
| CHEMBL30846 | — | — | 1 | 5.15 |
| CHEMBL277738 | — | — | 1 | 5.09 |
| CHEMBL31428 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL430539 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL32002 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL285046 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL285146 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL285779 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL31675 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL30618 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL31404 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL31881 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL283046 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL287023 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL286413 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL265984 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL31466 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL281299 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL284690 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL31880 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL30846 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL277738 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL31428 | — | IC50 | = | 10000.0 | nM | 5.00 |